Figure 4
The effect of activating and antagonist ligands on different ASIC and GABAAR subtypes expressed in X. laevis (•) and X. borealis (
) oocytes.
pH-dependence of steady-state desensitisation (open symbols, dashed lines) and activation (closed symbols, solid lines) of (a) ASIC1a, (b) ASIC1b, (c) ASIC2a and (d) ASIC3 (n = 9–12). (e) Concentration-effect curve for inhibition of rat ASIC1a by Pc1a (n = 9–12). (f) Concentration-effect curve for inhibition of rat ASIC3 by APETx2 (n = 9). Concentration-effect curves for GABA activation of the (g) α1β2γ2L, (h) α5β2γ2L and (i) α5β3γ2L subtypes of GABAARs (n = 9–10). Error bars indicate 95% confidence intervals.
