Figure 2
TMS restores cortical excitability after TBI.
Increase in stimulus-evoked electrophysiology responses in the intact, non-injured S1 after four-week TMS treatment in TBI rats. (a) The representative MUA recordings show enhanced responses in L4 of non-injured S1. Gray box represent duration of tactile stimulus. LFP maps of representative control, TBI and TBI + TMS rats show an increase in the amplitude of stimulus-evoked LFP response across the S1 depth in a TBI + TMS rat, compared to a TBI rat. (b) Post-stimulus time histograms of representative control, TBI and TBI + TMS rats show an increase in the number of MUA responses across the S1 depth in a TBI + TMS rat, compared to a TBI rat not subjected to TMS therapy. (c) The average number of MUA responses across the S1 depth shows an increase in L2–3, L4 and L5 in TBI + TMS rats (n = 10), compared to TBI rats (n = 10; *P < 0.05; **P < 0.01). (d) The averaged amplitude of stimulus-evoked LFP response across the S1 depth shows an increase in L2–3 and L4 in TBI + TMS rats (n = 10), compared to TBI rats (n = 10; *P < 0.05; **P < 0.01). Recording was performed once for each individual animal.
