Figure 3 | Scientific Reports

Figure 3

From: Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress

Figure 3

Prior exposure to NO inhibits ER stress-induced XBP1 mRNA splicing.

(a) NO attenuates Tg-stimulated XBP1 mRNA splicing. Cells were preincubated with 100 μM NO for 30 min and then stimulated with 10 μM Tg for 2 h. Splicing of XBP1 mRNA was assessed by performing RT-PCR. (b) Quantification of XBP1 mRNA splicing is shown for data in (a). Values are expressed as mean ± s.e.m. (n = 4; P < 0.01 by ANOVA).

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