Figure 1 | Scientific Reports

Figure 1

From: Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities

Figure 1

Strategy of the co-modification of TRAIL mutant with PEG and MMAE.

PEG refers to methoxy- polyethylene glycol -maleimide (mPEG-MAL, 5000 Da). Monomethyl Auristatin E is abbreviated as MMAE and linker (Val-Cit) represents maleimidocaproyl-valine-citrulline; Self-immolative spacer refers to p-aminobenzylcarbamate. N109C represents the Asn-109 to Cys mutation of TRAIL (95–281 amino acids). The arrow indicates the Cathepsin B cleavage site of the linker.

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