Figure 5
From: Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities
In vivo antitumor activities of PEG-TRAIL-vcMMAE.
(a) In vivo antitumor activities of TRAIL and its conjugates. When tumor volume reached ~50 mm3, all the samples were administered intravenously once every two days for 4 times. Tumor volume was calculated by the formula: V = L × W2/2, L and W refer to longitudinal and transverse tumor diameters respectively. ***P < 0.001 (two-way analysis of variance, ANOVA). (b) Dissected tumor from different experimental groups. (c) Tumor growth inhibition rate was calculated according to the tumor weight. *P < 0.05 and ***P < 0.001 (one-way analysis of variance, ANOVA). (d) TUNEL analysis of histological sections from different groups. Representative apoptotic cells were arrowed. Magnification 400×.
