Table 1 Comparison of pharmacokinetic parameters after administering N109C, N109C-vcMMAE and PEG-N109C-vcMMAE to rats at 1 mg/rat i.v. (5 mg/kg) (n = 4).

From: Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities

Pharmacokinetic

N109C

N109C-vcMMAE

PEG-N109C-vcMMAE

parameters

AUCinf1 (mg/L*h)

178.16 ± 80.18

756.63 ± 368.49

1917.52 ± 555.72

t1/22 (h)

1.91 ± 0.94

4.26 ± 3.34

11.54 ± 6.20

CL3 (L/h/kg)

0.034 ± 0.017

0.0070 ± 0.0030

0.0050 ± 0.0010

  1. 1AUCinf: Area under the curve from zero to infinity.
  2. 2t1/2: Half-life.
  3. 3CL: Clearance.
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