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Figure 4

From: Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative

Figure 4

(A) Phylogenetic tree of EpoK and CYPome of So ce56. The tree was constructed by using protein sequences and the “One Click” mode of the online phylogenetic analysis tool from Information Génomique et Structurale, Marseille, France. The bar in the left corner indicates 0.4 amino acid substitutions per amino acid for the branch length65. (B) HPLC chromatogram of epothilone D (dashed line) and its conversion by CYP267B1/Fdx8/FdR_B (solid line).

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