Figure 1
From: The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
The effects of ganciclovir were investigated in Theiler’s murine encephalomyelitis virus (TMEV) infected C57BL/6 mice and in corresponding non-infected controls.
Virus infection (A,B) and T cell infiltration (C,D) were confirmed by immunohistochemical stainings in the hippocampus. Total microglia numbers were analyzed by Iba1 staining, while proliferating microglia were visualized by double staining for Iba1/Ki67 (E,F). No effects of ganciclovir on virus infected neurons and T cell and microglial numbers could be observed between TMEV groups. Each bar represents the mean ± SEM, n = 6 per time point and group.
