Table 3 Stratified analysis on the associations of rs139293 in APOBEC3H with lung cancer risk.

From: The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population

Variables

Casesa

Controlsa

OR (95% CI)b

P-valueb

P-valuec

Age (years)

 <60

422/94/8

402/125/7

0.78 (0.60–1.03)

0.080

0.723

 ≥60

535/112/12

510/172/8

0.73 (0.57–0.93)

0.012

Sex

 Male

676/143/16

624/196/10

0.79 (0.64–0.98)

0.035

0.340

 Femal

281/63/4

288/101/5

0.65 (0.47–0.92)

0.014

Smoking states

 Never

374/77/6

460/164/8

0.65 (0.49–0.86)

0.003

0.122

 Ever

583/129/14

452/133/7

0.87 (0.69–1.11)

0.273

Smoking Levels

 ≤25 (Pack-years)

177/42/5

214/65/2

1.02 (0.69–1.52)

0.906

0.393

 >25 (Pack-years)

406/87/9

238/68/5

0.82 (0.60–1.11)

0.205

Histological types

 Squamous carcinoma

352/63/5

912/297/15

0.65 (0.48–0.88)

0.005

0.163

 Adenocarcinoma

605/143/15

912/297/15

0.84 (0.68–1.02)

0.082

  1. aMajor homozygote/heterozygote/minor homozygote.
  2. bAfter adjusting for age, gender and pack-year of smoking where appropriate assuming an additive genetic model.
  3. cP for heterogeneity.
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