Figure 5 | Scientific Reports

Figure 5

From: Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity

Figure 5

Effects of H2S on steroid sensitivity.

The expression of HDAC2 protein was decreased in lung tissue of COPD and smokers compared with nonsmokers (a,b). CS-exposed U937 cells were treated with dexamethasone alone or in combination with GYY4137. TNF-a (c) and IL-8 (d) release were evaluated by enzyme-linked immunosorbent assay. (e) TNF-a levels in alveolar macrophages from CS exposed rats were evaluated. *P < 0.05, **P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. CS. n = 5–6 experiments, DEX: dexamethasone.

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