Figure 1 | Scientific Reports

Figure 1

From: Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth

Figure 1

H-FIRE treatment in a 3D tumor mimic.

Schematics of (A) traditional monopolar IRE pulse and (B) high frequency bipolar burst. (C) The experimental setup with electrodes inserted into the 3D tissue mimic. Live [green] and dead [red] regions of the tissue mimic after treatment with eighty bursts containing (D) 2, (E) 24 and (F) 50 bipolar 2 μs pulses with a 2 μs delay between alternating pulses. (G) Diffuse treatment of 50 bipolar 2 μs pulses with 20 ms between alternating pulses. Scale bar represents 2 mm.

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