Table 2 MiRNA profiles and diagnostic performance in training and validation datasets.

Targeted Disease vs Control	miRNA	Training Dataset			Validation Dataset
Targeted Disease vs Control	miRNA	fold-change	p-value	AUC	fold-change	p-value	AUC
LC vs CHB	miR-18a-5p	0.5344	0.0047	0.664	0.4108	<0.0001	0.69
	miR-21-5p	0.711	0.0079	0.654	0.3962	<0.0001	0.76
	miR-29c-3p	0.3451	<0.0001	0.787	0.4564	<0.0001	0.767
	miR-106b-5p	0.509	0.0001	0.726	0.4567	<0.0001	0.686
	miR-122-5p	0.4433	0.0003	0.709	0.2796	<0.0001	0.787
	miR-185-5p	0.4472	0.0084	0.653	0.4555	<0.0001	0.703
LC vs HC	miR-1	3.5899	<0.0001	0.798	3.1534	<0.0001	0.879
	miR-146a-5p	3.6013	<0.0001	0.856	3.5424	<0.0001	0.919
	miR-451a	0.1242	<0.0001	0.894	0.1131	<0.0001	0.846
CHB vs HC	miR-21-5p	1.629	<0.0001	0.82	2.9823	<0.0001	0.927
	miR-27a-3p	3.3701	<0.0001	0.842	7.6229	<0.0001	0.937
	miR-122-5p	6.4798	<0.0001	0.853	10.0554	<0.0001	0.917
	miR-146a-5p	6.0375	<0.0001	0.946	10.7542	<0.0001	0.992

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