Table 1 Association between rs3731249, rs113650570 and rs36228834 genotypes and risk of developing B-cell childhood acute lymphoblastic leukaemia.
SNP | RAFa | ORb (95% CIc) | P-value | |
|---|---|---|---|---|
Cases | Controls | |||
rs3731249 | ||||
UK GWAS | 0.05 | 0.03 | 2.48 (1.77–3.48) | 1.22 × 10−07 |
German GWAS | 0.08 | 0.03 | 2.46 (1.84–3.28) | 9.42 × 10−10 |
Replication | 0.05 | 0.02 | 2.24 (1.48–3.39) | 1.40 × 10−04 |
Combined | 2.42 (1.99–2.93) | 3.45 × 10 − 19 | ||
Phet = 0.92, I2 = 0% | ||||
rs36228834 | ||||
UK GWAS | 0.05 | 0.03 | 2.52 (1.80–3.52) | 6.22 × 10−08 |
German GWAS | 0.08 | 0.03 | 2.44 (1.83–3.26) | 1.25 × 10−09 |
Replication | 0.05 | 0.02 | 2.19 (1.45–3.30) | 1.90 × 10−04 |
Combined | 2.41 (1.99–2.92) | 4.41 × 10 − 19 | ||
Phet = 0.86, I2 = 0% | ||||
rs113650570 | ||||
UK GWAS | 0.05 | 0.03 | 2.52 (1.80–3.52) | 6.05 × 10−08 |
German GWAS | 0.08 | 0.03 | 2.44 (1.83–3.26) | 1.20 × 10−09 |
Replication | 0.05 | 0.02 | 2.09 (1.39–3.16) | 4.10 × 10−04 |
Combined | 2.39 (1.97–2.89) | 9.21 × 10 − 19 | ||
Phet = 0.77, I2 = 0% | ||||