Table 1 Association between rs3731249, rs113650570 and rs36228834 genotypes and risk of developing B-cell childhood acute lymphoblastic leukaemia.

From: The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A

SNP

RAFa

ORb (95% CIc)

P-value

Cases

Controls

rs3731249

 UK GWAS

0.05

0.03

2.48 (1.77–3.48)

1.22 × 10−07

 German GWAS

0.08

0.03

2.46 (1.84–3.28)

9.42 × 10−10

 Replication

0.05

0.02

2.24 (1.48–3.39)

1.40 × 10−04

Combined

  

2.42 (1.99–2.93)

3.45 × 10 19

    

Phet = 0.92, I2 = 0%

rs36228834

 UK GWAS

0.05

0.03

2.52 (1.80–3.52)

6.22 × 10−08

 German GWAS

0.08

0.03

2.44 (1.83–3.26)

1.25 × 10−09

 Replication

0.05

0.02

2.19 (1.45–3.30)

1.90 × 10−04

Combined

  

2.41 (1.99–2.92)

4.41 × 10 19

    

Phet = 0.86, I2 = 0%

rs113650570

 UK GWAS

0.05

0.03

2.52 (1.80–3.52)

6.05 × 10−08

 German GWAS

0.08

0.03

2.44 (1.83–3.26)

1.20 × 10−09

 Replication

0.05

0.02

2.09 (1.39–3.16)

4.10 × 10−04

Combined

  

2.39 (1.97–2.89)

9.21 × 10 19

    

Phet = 0.77, I2 = 0%

  1. aRisk allele frequency (RAF).
  2. bOdds ratio.
  3. c95% Confidence Interval.