Table 1 Summary of key results for vaccine trials for Sm-LAMP.
Antibody end point titres | Vaccine trial 1 | Vaccine trial 2 | |
|---|---|---|---|
Insoluble LAMP | Insoluble LAMP | Soluble LAMP | |
IgG | 1:32 000 (1:100) | 1:128 000 (1:100) | 1:256 000 (1:100) |
IgG1 | 1:128 000 (1:100) | 1: 32 000 (1:100) | 1:256 000 (1:100) |
IgG2a | 1:64 000 (1:50) | 1:128 000 (1:50) | 1:64 000 (1:50) |
IgG2b | 1:128 000 (1:50) | 1:32 000 (1:50) | 1:128 000 (1:50) |
IgG3 | NR | NR | 1:64 000 |
Worm counts | |||
Females -% reduction | 20.93 (p = 0.04) | 35.7 (p = 0.019) | 16 (NS) |
Total -% reduction | 16.21 (p = 0.04) | 25 (p = 0.01) | 8.7 (NS) |
Egg counts | |||
Liver -% reduction | 20 (p = 0.021) | 38 (p = 0.015) | 13 (NS) |
Intestine -% reduction | 21 (p = 0.011) | 49 (NS) | 30 (NS) |
Faecal -% reduction | 51.9 (p = 0.001) | 60 (p = 0.009) | 54 (p = 0.035) |
Faecal egg reduction per female | 56.2 (NS) | 22.3 (NS) | 58.6 (NS) |
