Figure 4
From: Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory
RNAi silencing of GAP-2 and GAP-3 phenocopy the mutant phenotypes.
Negative conditioning assays were combined with RNA interference experiments using eri-1(mg366);lin-15B(n744) RNA sensitized worms, fed against (A) gap-1 (n = 3), (B) gap-2 (n = 13, p = 2.72 × 10−7) and (C) gap-3 (n = 9, p = 3.75 × 10−5) dsRNA carrying bacteria. Dark grey represents the same strain fed with bacteria carrying an empty GFP marker dsRNA as reference. N: naïve, C: conditioned, R: recovered animals (see Materials and Methods for details). Error bars indicate SD and asterisks indicate significant differences (***P < 0.001).
