Figure 3
Aging synchronization in multiple tissues.
(a) Heatmap of tissue co-aging in adipose, artery, heat, lung, muscle, nerve and blood tissues. The number in each square in the lower triangle indicates the co-aging coefficient between a tissue pair; and the sample number for each tissue is also presented in the top of the sample column. (b) Scatter plot of age rank correlation for two highly correlated tissues lung and blood and the regression line. Spearman-R value represents the Spearman correlation coefficient between the ranks defined by the two tissues across all samples. (c) Scatter plot of age rank correlation for two relatively uncorrelated tissues muscle and blood and the regression line. (d) Scatter plot of age rank correlation for heart, lung and blood; the axis ranges from 0 to 60 indicating the rank of each sample (in total 59 donors with data in all these 3 tissues); the chronological ages are marked for some representative samples and the outliers are highlighted in red. (e) Correlation between age rank deviation and age in artery and nerve. The shaded area indicates the confidence interval of the regression line. “p-value” indicates the p-value for regression coefficient being deviated from 0. (f) Correlation between rank deviation and age in lung and blood.
