Table 1 Number of age-associated genes in 9 human tissues and permutation test.

From: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Tissues

Sample Size

Aging genea

Permutationb

Up

Down

Overall

Frequency

Number

Adipose

94

652

482

1134

0

2.16

Artery

112

2258

824

3082

0

5.11

Heart

83

374

454

828

0

2.43

Lung

119

329

547

876

0

2.95

Muscle

138

766

121

887

0

1.53

Nerve

88

116

67

183

0

1.47

Skin

96

6

6

12

36

7.40

Thyroid

105

2

1

3

10

0.34

Blood

156

1381

1906

3287

5

82.60

  1. aNumber of significant genes after adjusting for 3 types of confounding factors: (1) gender, (2) the top three genotype PCs and (3) among the top 5 gene expression PCs, the PCs not significantly (p-value > 0.05) correlated with age and removing 20% low expressed genes in the original expression data. Columns “Up”, “Down” and “Overall” list the number of up-regulated, down-regulated and overall aging genes, respectively.
  2. bResults of aging genes from 1,000 permutation tests. The column “Frequency” lists the frequencies of identifying equal or more significant genes in 1,000 permuted datasets than those in the original one. The column “Number” lists the average number of aging genes in 1,000 permutation runs.
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