Figure 7
From: De novo KCNB1 mutations in infantile epilepsy inhibit repetitive neuronal firing
EEG and brain MRI features of patients with KCNB1 mutations.
(A,B) Interictal EEG tracing of patient 1 at 18 months of age and patient 2 at 2 years and 11 months. (A) Diffuse irregular polyspikes and waves with intermittent focal spikes during the sleep state in patient 1. (B) Diffuse irregular slow spikes and waves and polyspikes and waves during the sleep state in patient 2. (C) Ictal EEG tracing of patient 1 at 23 months showed runs of diffuse slow spike and wave discharges beginning at 2 Hz and accelerating to 3–3.5 Hz irregular spikes and waves, followed by a mixture of irregular spikes intermingled with arrhythmic slow activities that accompanied generalized clonic seizures. Seizures lasted approximately 50 seconds. (D–E) T2-weighted axial brain MRI of patient 1. (D) MRI at 9 months showed normal findings. (E) MRI at 2 years 2 months showed slight cortical atrophy especially in the frontal lobes. (F) T2-weighted axial brain MRI of patient 2 showed normal findings. m, months; y, years
