Table 2 Overall and subgroup analysis of ACE gene I/D polymorphism with OSAS susceptibility under three genetic models.
Groups | Studies | I versus D | II versus DD | II plus ID versus DD | |||
|---|---|---|---|---|---|---|---|
OR, 95% CI, P | I 2 | OR, 95% CI, P | I 2 | OR, 95% CI, P | I 2 | ||
Overall | 16 | 1.204, 0.923–1.570, 0.170 | 85.5% | 1.337, 0.829–2.163, 0.237 | 81.1% | 1.153, 0.827–1.607, 0.401 | 75.4% |
Race | |||||||
Asian | 9 | 1.443, 0.912–2.284, 0.118 | 90.3% | 2.019, 0.867–4.701, 0.103 | 87.6% | 1.453, 0.827–2.555, 0.194 | 81.5% |
White | 4 | 0.890, 0.600–1.319, 0.560 | 51.9% | 0.812, 0.369–1.787, 0.604 | 52.7% | 0.742, 0.446–1.233, 0.250 | 34.3% |
Mixed | 3 | 1.082, 0.923–1.570, 0.691 | 68.3% | 1.120, 0.606–2.071, 0.718 | 49.8% | 1.175, 0.608–2.270, 0.631 | 75.5% |
Language | |||||||
English | 9 | 1.107, 0.878–1.396, 0.389 | 70.5% | 1.183, 0.781–1.792, 0.426 | 63.6% | 1.039, 0.770–1.403, 0.802 | 58.1% |
Chinese | 7 | 1.421, 0.725–2.785, 0.306 | 92.1% | 2.293, 0.651–8.080, 0.197 | 89.3% | 1.618, 0.678–3.865, 0.279 | 85.6% |
Study design | |||||||
Retrospective | 13 | 1.334, 0.945–1.883, 0.101 | 86.7% | 1.671, 0.892–3.132, 0.109 | 83.0% | 1.349, 0.884–2.060, 0.165 | 76.5% |
Prospective | 3 | 0.854, 0.650–1.121, 0.255 | 48.4% | 0.759, 0.469–1.230, 0.263 | 35.8% | 0.714, 0.392–1.298, 0.269 | 70.2% |
Control source | |||||||
Hospital-based | 10 | 1.325, 0.865–2.031, 0.196 | 89.3% | 1.762, 0.799–3.885, 0.160 | 86.3% | 1.278, 0.763–2.140, 0.352 | 79.8% |
Population-based | 6 | 1.055, 0.779–1.429, 0.729 | 70.0% | 1.035, 0.616–1.740, 0.895 | 58.7% | 1.052, 0.655–1.688, 0.835 | 69.6% |
Sample size | |||||||
<300 subjects | 13 | 1.281, 0.861–1.905, 0.222 | 86.6% | 1.601, 0.781–3.279, 0.199 | 82.1% | 1.319, 0.802–2.171, 0.275 | 77.1% |
≥300 subjects | 3 | 1.012, 0.725–1.413, 0.945 | 85.5% | 1.014, 0.540–1.904, 0.965 | 83.8% | 0.906, 0.608–1.349, 0.627 | 75.3% |
Obesity | |||||||
BMI ≥ 30 kg/m2 | 7 | 1.135, 0.902–1.428, 0.280 | 60.6% | 1.261, 0.834–1.906, 0.271 | 53.2% | 1.137, 0.870–1.485, 0.346 | 38.2% |
BMI < 30 kg/m2 | 6 | 1.708, 1.047–2.785, 0.032 | 79.8% | 2.862, 0.979–8.373, 0.055 | 78.1% | 1.871, 0.891–3.926, 0.098 | 72.2% |
Hypertension | |||||||
With | 5 | 2.320, 1.587–3.390, 0.000 | 58.3% | 3.806, 1.865–7.765, 0.000 | 48.2% | 2.763, 1.485–5.142, 0.001 | 45.9% |
Without | 5 | 1.255, 0.538–2.926, 0.600 | 93.5% | 1.815, 0.357–9.231, 0.472 | 92.7% | 1.206, 0.515–2.824, 0.667 | 81.2% |
Mixed | 10 | 1.078, 0.826–1.407, 0.581 | 73.1% | 1.047, 0.644–1.701, 0.854 | 63.9% | 1.029, 0.704–1.502, 0.884 | 67.6% |
