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Figure 2

From: H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps

Figure 2

Cross-reactive hemagglutination inhibition (HAI) responses of 2009–10, 2010–11 and 2014–15 Northern Hemisphere (NH) seasonal influenza vaccines against epidemic influenza A (H3) viruses.

Serum samples were collected from healthy adults immunized with 2009–10, 2010–11 and 2014–15 NH egg-based or cell-based vaccine. Post-vaccination (post-vac) HAI titers against the H3 vaccine prototype virus and representative isolates of the latest H3N2 epidemic strains were determined by using 1% guinea pig erythrocytes. There were 24 post-vac sera each from adults vaccinated with 2009–10 and 2010–11 NH egg-based vaccines and 2014–15 NH cell-based vaccine. There were also 30 post-vac sera from adults vaccinated with 2014–15 NH egg-based vaccine. The H3 strains in the testing panel included egg-grown A/Texas/50/2012 (TX/12e), A/Switzerland/9715293/2013 (SWZ/13e), A/Palau/6759/2014 (PL/14e), A/North Carolina/13/2014 (NC/14e) and cell-grown A/Texas/50/2012 (TX/12c), A/Switzerland/9715293/2013 (SWZ/13c), A/North Carolina/13/(NC/14c) and A/Michigan/15/2014 (MI/14c). The proportions of subjects with post-vac HAI titer of ≥40, ≥80 and ≥160 were plotted. *Indicates the H3 prototype virus of 2014–15 NH egg-based vaccine. Dotted horizontal line indicates 50% achievement. ND: not determined due to limited volumes of sera.

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