Figure 1 | Scientific Reports

Figure 1

From: Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells

Figure 1

LSD1 expression is associated with sensitivity to EGFR inhibition in ovarian cancer cell lines.

(a) Protein levels were detected via western blotting in whole-cell extracts (LSD1 and EGFR) or histone protein extracts (H3K4me1 and me2) from ovarian epithelial HOSEpiC cells and HO8910, SKOV3 and 3AO ovarian cancer cells. (b) HO8910, SKOV3 and 3AO cells were treated with the EGFR inhibitor AG1478 (10 μM) for 24 h, after which the levels of LSD1 protein and H3K4 methylation were analyzed via western blotting. α-tubulin and histone H3: loading control.

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