Figure 5 | Scientific Reports

Figure 5

From: The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma

Figure 5

Inhibition of STAT signaling blocks lipogenic effect of p17.

HepG2 cells were pre-incubated for 2 h with the STAT1 inhibitor Fludarabine (5 μM) or with the STAT3 inhibitor 5,15 DPP (5 μM) prior to stimulation with 10 μg/ml p17 for 18 hour. qRT-PCR of LXRα (A), SREBP1c (B) and FAS (C). Values are normalized relative to GAPDH mRNA and are expressed relative to those of untreated cells, which were arbitrarily set to 1. *P < 0.05 versus not treated cells. #P < 0.05 versus p17 stimulated cells.

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