Figure 1
From: MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition
MiR-129-3p is highly expressed in MDA-MB-231/Doc resistant cells and stably transfected cells.
(A) MTT assay showing that MDA-MB-231/Doc cells were more resistant to docetaxel than MDA-MB-231 cells. (B) Colony formation assay revealed a significant increase in proliferative ability of MDA-MB-231/Doc cells treated with 10 nM docetaxel. (C) Quantitative real-time PCR analysis of miR-129-3p and miR-129-5p expression in parental MDA-MB-231 cells compared to docetaxel-resistant MDA-MB-231/Doc cells. (D,E) Quantitative real-time PCR analysis of miR-129-3p and miR-129-5p expression in MDA-MB-231 and MCF-7 cells stably transfected with miR-129. Each bar represents the mean ± SD. p values were calculated using Student’s t-test (*p < 0.05, **p < 0.01, ***p < 0.001).
