Table 4 Univariate and multivariate Cox regression analysis of the association with RFS.
From: The influence of cancer tissue sampling on the identification of cancer characteristics
Characteristic | Subcategory | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | ||
Training cohort | |||||
Prognostic gene pairs | High vs. low | 3.90(2.54–5.98) | 4.12E–10 | 3.60(2.24–5.76) | 9.61E–08 |
Age | >49 vs. ≤49 | 0.87(0.57–1.32) | 0.52 | 0.95(0.60–1.50) | 0.86 |
Grade | I vs. II, III | 1.81(1.01–3.23) | 0.04 | 1.19(0.65–2.18) | 0.57 |
Size | >2 cm vs. ≤2 cm | 1.97(1.29–3.00) | 1.51E–03 | 1.74(1.10–2.74) | 0.02 |
Validation cohort | |||||
Prognostic gene pairs | High vs. low | 2.45(1.11–5.43) | 0.03 | 2.19(0.95–5.06) | 0.06 |
Age | >66 vs. ≤66 | 0.7(0.35–1.38) | 0.31 | 0.74(0.37–1.49) | 0.41 |
Grade | I vs. II, III | 1.41(0.70–2.86) | 0.33 | 1.12(0.53–2.36) | 0.76 |
Size | >18 mm vs. ≤18 mm | 1.78(0.91–3.50) | 0.09 | 1.68(0.85–3.34) | 0.14 |
