Figure 7 | Scientific Reports

Figure 7

From: Complex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein

Figure 7

Root mean square deviations of the protein backbone grouped according to amino acid relative to (A) the starting structure (wild type murine protein pdb code 1AG2) and (B) compared to the average structure calculated for each protein.

Solid line represents data from 2 replicate runs of the wildtype MoPrP; dotted line is MoPrP-S169N; dashed line is MoPrP-N173T; dot-dash line is MoPrP-S169N/N173T. Ramachandran plots of the φ–ψ dihedral angles of the backbone of the Ser/Asn169 amino acid for structures output over the course of molecular dynamics simulations of (C) MoPrP—structures output from both the previous and new simulations are used (D) MoPrP-S169N (E) MoPrP-N173T (F) MoPrP-S169N/N173T.

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