Table 2 Main results for the MTR A2756G mutation in the meta-analysis.
From: Role of genetic mutations in folate-related enzyme genes on Male Infertility
MTR A2756G(rs1805087) | Na | GG vs AA | AG vs AA | AG/GG vs AA | GG vs AG/AA | G vs A | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | OR(95%CI) | Pb | FDRd | OR(95%CI) | Pb | FDRd | OR(95%CI) | Pb | FDRd | OR(95%CI) | Pb | FDRd | OR(95%CI) | Pb | FDRd | |
Total | 6 | 2.05(1.36-3.09) | 0.615 | 0.003 | 1.07(0.88-1.31) | 0.408 | 0.483 | 1.20(0.99-1.44) | 0.666 | 0.071 | 2.09(1.39-3.13) | 0.561 | 0.000 | 1.28(1.09-1.50) | 0.353 | 0.003 |
Consistent to HWE | 5 | 1.74(1.03-2.22) | 0.627 | 0.040 | 1.14(0.92-1.41) | 0.665 | 0.217 | 1.20(0.98-1.47) | 0.522 | 0.166 | 1.67(0.99-2.83) | 0.708 | 0.055 | 1.22(1.02-1.45) | 0.433 | 0.030 |
Ethnicity | ||||||||||||||||
 Asian | 3 | 2.23(0.83-5.96) | 0.736 | 0.165 | 1.17(0.85-1.60) | 0.945 | 0.437 | 1.24(0.91-1.67) | 0.961 | 0.410 | 2.17(0.81-5.78) | 0.728 | 0.185 | 1.27(0.97-1.68) | 0.929 | 0.128 |
 European | 2 | 1.55(0.82-2.92) | 0.200 | 0.174 | 1.12(0.84-1.49) | 0.135 | 0.437 | 1.17(0.89-1.53) | 0.080 | 0.410 | 1.49(0.79-2.79) | 0.285 | 0.215 | 1.18(0.93-1.48) | 0.062 | 0.166 |
Subgroup | ||||||||||||||||
 Azoospermia | 4 | 2.25(1.36-3.73) | 0.744 | 0.005 | 1.06(0.80-1.41) | 0.622 | 0.700 | 1.23(0.95-1.60) | 0.972 | 0.153 | 2.31(1.41-3.79) | 0.592 | 0.001 | 1.35(1.09-1.68) | 0.602 | 0.007 |
Consistent to HWE | 3 | 1.83(0.95-3.52) | 0.878 | 0.069 | 1.13(0.83-1.54) | 0.813 | 0.426 | 1.21(0.91-1.62) | 0.919 | 0.379 | 1.79(0.94-3.42) | 0.853 | 0.079 | 1.25(0.98-2.60) | 0.988 | 0.076 |
 OATc | 5 | 1.70(1.02-2.83) | 0.146 | 0.108 | 0.96(0.73-1.26) | 0.723 | 0.780 | 1.06(0.83-1.37) | 0.569 | 0.780 | 1.77(1.07-2.93) | 0.146 | 0.108 | 1.16(0.93-1.43) | 0.128 | 0.308 |
Consistent to HWE | 4 | 1.29(0.63-2.63) | 0.095 | 0.481 | 1.03(0.76-1.38) | 0.804 | 0.862 | 1.05(0.79-1.39) | 0.409 | 0.751 | 1.28(0.63-2.59) | 0.113 | 0.492 | 1.07(0.83-1.37) | 0.125 | 0.606 |
