Table 2 Linear regression between GRS and age at menarche or age at natural menopause among controls.

From: Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk

Genetic risk score (GRS)

βa

95% CI

P b

Age at menarche

 GRS1c

 <27

0

Reference

  

 27-<30

−0.14

−0.46

0.19

0.33

 ≥30

−0.39

−0.71

−0.07

0.044

 Continuous

−0.27

−0.47

−0.08

0.007

Weighed GRS1

 <1.86

0

Reference

  

 1.86-<2.19

−0.08

−0.31

0.17

0.55

 ≥2.19

−0.27

−0.51

−0.04

0.024

 Continuous

−0.40

−0.66

−0.14

0.002

Age at natural menopause

 GRS2d

 <21

0

Reference

  

 21-<24

0.87

0.16

1.59

0.016

 ≥24

2.16

1.31

3.01

10−6

 Continuous

0.25

0.13

0.37

10−4.4

Weighed GRS2d

 <5.85

0

Reference

  

 5.85-<6.74

0.66

−0.12

1.44

0.0002

 ≥6.74

1.49

0.71

2.27

0.095

 Continuous

0.57

0.26

0.89

0.0004

  1. aMean difference in age at menarche or age at natural menopause.
  2. bAdjusted for age and race.
  3. cGRS1 was calculated based on the 26 SNPs in Table 2.
  4. dGRS2 was calculated based on the 22 SNPs in Table 2.
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