Table 3 Associations of endometrial cancer with total numbers of menstrual cycles and genetic risk scores on menarche and menopause among all subjects.

From: Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk

Variable

Case/Control

ORa

95%CI

ORb

95%CI

ORc

95%CI

ORd

95%CI

ORe

95%CI

TNMC

 Continuous*

459/538

1.29

1.14

1.46

1.40

1.22

1.60

1.33

1.15

1.53

1.28

1.10

1.50

1.27

1.07

1.50

 ≤411.5

173/269

1.00

  

1.00

  

1.00

  

1.00

  

1.00

  

 >411.5

286/269

1.65

1.28

2.13

1.86

1.42

2.43

1.72

1.29

2.28

1.52

1.10

2.09

1.49

1.07

2.08

GRS1

 Continuous

482/571

1.04

1.01

1.07

1.04

1.00

1.07

1.03

1.00

1.07

1.01

0.97

1.05

1.01

0.97

1.05

 ≤27

216/266

1.00

  

1.00

  

1.00

  

1.00

  

1.00

  

 >27

296/275

1.33

1.04

1.69

1.30

1.01

1.66

1.29

1.00

1.68

1.13

0.85

1.50

1.06

0.79

1.43

GRS2

 Continuous

414/546

1.00

0.96

1.05

1.00

0.95

1.05

1.01

0.96

1.07

1.01

0.96

1.07

1.00

0.94

1.06

 ≤21

212/275

1.00

  

1.00

  

1.00

  

1.00

  

1.00

  

 >21

202/271

0.97

0.75

1.25

0.98

0.75

1.27

1.01

0.77

1.33

1.06

0.79

1.43

0.97

0.71

1.33

  1. *100 menstrual cycles per unit of increment.
  2. ano adjustment.
  3. badjusted for age, race and education.
  4. cadjusted for age, race, education, family cancer of history, OC use and estrogen.
  5. dadjusted for age, race, education, family cancer of history, OC use, estrogen use and BMI.
  6. eadjusted for age, race, education, family cancer of history, OC use, estrogen use and BMI change.
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