Table 3 Inhibitory effects of compounds 1–4 on superoxide anion generation and elastase release by human neutrophils.

From: Glaucumolides A and B, Biscembranoids with New Structural Type from a Cultured Soft Coral Sarcophyton glaucum

Compound

Superoxide anion

 

Elastase release

 

IC50 (μM)b

Inh %a

IC50 (μM)

Inh %

1

2.79 ± 0.66

88.42 ± 3.97

***

3.97 ± 0.10

88.94 ± 6.96

***

2

2.79 ± 0.32

91.75 ± 3.08

***

3.97 ± 0.10

103.25 ± 1.89

***

3

>10

15.33 ± 4.15

*

>10

15.13 ± 3.58

*

4

>10

12.40 ± 2.56

**

>10

27.12 ± 3.08

***

Idelalisib

0.07 ± 0.01

102.81 ± 2.21

***

0.28 ± 0.09

99.56 ± 4.19

***

  1. aPercentage of inhibition (Inh %) at 10 μM concentration. Results are presented as mean ± S.E.M. (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control value.
  2. bConcentration necessary for 50% inhibition (IC50).
Back to article page