Table 2 Micro-CT assessment of trabecular bone region at the distal femur and cortical bone region at the femoral midshaft.

From: Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass and Bone Strength of Intact Bones in Adult Male Rats

Variables

Week 3

Week 6

Week 9

Vehicle

Scl-Ab

Vehicle

Scl-Ab

Vehicle

Scl-Ab

Distal femur - Trabecular region

 BV/TV

0.07 ± 0.04

0.08 ± 0.02

0.07 ± 0.03

0.20 ± 0.03**

0.09 ± 0.03

0.39 ± 0.06**

 BMD (mg HA/cm3)

708 ± 36

726.3 ± 23.4

704 ± 16

760 ± 10**

721 ± 16

804 ± 10**

 BMC (mg HA)

1,677 ± 864

2,008 ± 677

1,528 ± 644

5,081 ± 1,167**

2,187 ± 657

11,461 ± 2,895**

 Tb.N (1/mm)

1.07 ± 0.27

1.11 ± 0.26

1.00 ± 0.32

1.80 ± 0.30**

1.37 ± 0.28

2.16 ± 0.18**

 Tb.Th (mm)

0.05 ± 0.01

0.07 ± 0.01*

0.06 ± 0.01

0.11 ± 0.01**

0.06 ± 0.01

0.18 ± 0.03**

 Tb.Sp (mm)

0.88 ± 0.36

0.88 ± 0.25

1.03 ± 0.33

0.46 ± 0.09**

0.69 ± 0.16

0.28 ± 0.04*

Femoral midshaft - Cortical region

 BMD (mg HA/cm3)

907 ± 25

924 ± 22

921 ± 29

967 ± 19

988 ± 24

970 ± 16

 BMC (mg HA)

29,583 ± 2,143

31,525 ± 2,852

30,404 ± 3,244

36,679 ± 3,095**

32,954 ± 1,675

38,839 ± 3,117**

 CSA (mm2)

8.67 ± 0.55

9.07 ± 0.70

8.77 ± 0.86

10.07 ± 0.69**

8.86 ± 0.32

10.64 ± 0.85**

 Ct.Th (mm)

0.67 ± 0.03

0.68 ± 0.05

0.67 ± 0.05

0.77 ± 0.04**

0.70 ± 0.05

0.86 ± 0.04**

 CSMI (mm4)

33.5 ± 4.4

36.1 ± 6.1

34.3 ± 5.3

39.0 ± 6.1

32.3 ± 3.1

39.6 ± 7.0*

 BSICSA

7,864 ± 570

8,380 ± 758

8,082 ± 862

9,750 ± 823**

8,760 ± 445

10,324 ± 829**

 BSICSMI

30,368 ± 4,224

33,384 ± 6,056

31,615 ± 5,192

37,794 ± 6,328*

31,900 ± 2,960

38,053 ± 6,414*

  1. Values are mean ± SD, *P < 0.05; **P < 0.01 compared with vehicle at the same time point. Scl-Ab: sclerostin antibody; BV/TV: bone volume fraction; BMD: bone mineral density; BMC: bone mineral content; Tb.N: trabecular number; Tb.Th: trabecular thickness; Tb.Sp: trabecular spacing; CSA: cross sectional area; Ct.Th: cortical thickness; CSMI: cross sectional moment of inertia; BSICSA: CSA-derived bone strength index; BSICSMI: CSMI-derived bone strength index.
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