Table 3 Histomorphometric analysis of trabecular bone in the distal femur.

From: Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass and Bone Strength of Intact Bones in Adult Male Rats

Variable

Week 6

Week 9

Vehicle

Scl-Ab

Vehicle

Scl-Ab

MAR (μm/day)

0.57 ± 0.20

1.10 ± 0.07**

0.61 ± 0.09

1.23 ± 0.09**

MS/BS (%)

4.36 ± 1.35

16.1 ± 2.91**

4.48 ± 1.61

23.9 ± 6.59**

BFR (μm3/μm2/day)

2.59 ± 1.27

17.9 ± 4.05**

2.70 ± 0.99

29.1 ± 6.68**

  1. Values are mean ± SD, **P < 0.01 compared with vehicle at the same time point. Scl-Ab: sclerostin antibody; MAR: mineral apposition rate; MS/BS: mineralizing surface; BFR: bone formation rate.
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