Figure 4
From: Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO
Biodistribution of 99mTc-HMPAO-ENVs.
Mice were sacrificed at 0.5, 1, 3, 5 hr after 99mTc-HMPAO ENVs injection and radioactivity was measured for quantitative analysis of biodistribution (n = 4 for groups sacrificed at 0.5, 1 and 5 hr; n = 3 for a group sacrificed at 3 hr). As shown in SPECT images, 99mTc-HMPAO-ENVs were highly accumulated in liver, spleen and kidneys. Note that no significant uptake in brain unlike 99mTc-HMPAO used as a brain perfusion tracer. %ID/g represents counts of radioactivity normalized by injected dose and weights of organ. Data are presented as mean ± S.D.
