Figure 6

The interaction between pyruvate, 2-oxoglutarate and 2-hydroxyglutarate and central carbon metabolism.

2-hydroxyglutarate dehydrogenase (KEGG enzyme 1.1.99.2) catalyses a reversible reaction between 2-oxoglutarate and 2-hydroxyglutarate. All 3 metabolites feed into the tricarboxylic acid (TCA) cycle.