Figure 4
Canonical pathways in the human degenerative annulus fibrosus.
The bar graphs in A (scaled according to the ratio) and B (scaled according to the –log (p-value), are representative of the results from IPA ingenuity pathway analysis of microarray data from human degenerative versus non degenerative annulus fibrosus, showing the 5 most dysregulated canonical pathways in the degenerative annulus fibrosus. The canonical pathways involve interferon signalling as the top disrupted canonical pathway, followed by UDP-N-acetyl-D-galactosamine biosynthesis 1, dermatan sulfate biosynthesis, Wnt/beta-catenin signalling and xenobiotic metabolism signalling. The bar graphs are generated according to the number of the significant genes participating in each pathway. The ratios (in yellow) in graph A represent the number of significantly expressed genes over the total number of genes involved in each canonical pathway.
