Figure 6
From: Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
Muscimol, baclofen and tiagabine ameliorate microglial overactivation and protect against dopaminergic neuronal loss in the SN 4 days after LPS injection.
(A) Immunohistochemical staining showing TH-ir cells in the substantia nigra (scale bar: 0.2 mm). Stereological counting of TH-ir cells (n = 3–4) and Nissl-positive neurons (n = 3–4) in both sides in the control, LPS and LPS+ tiagabine groups is shown in the right panel. All data are presented as the mean ± SEM. *p < 0.05 and **p < 0.01. (B) Immunofluorescence staining for TH (red) and Iba-1 (green) in the SN (scale bar: 0.1 mm). Stereological counting of Iba-1-positive cells in both sides in the control, LPS and LPS+ tiagabine groups is shown in the right panel. All data are presented as the mean ± SEM. **p < 0.01 (n = 3–4).
