Figure 7 | Scientific Reports

Figure 7

From: Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E−/− Mice

Figure 7

Proteasome inhibitor BTZ reverses the phenotypic switching of the aortic smooth muslce cells in Ang II-infused apoE−/− mice.

(a) The representation of immunohistochemical staining for α-SMA in abdominal aorta from from Apo E−/− mice (left). Bar graph shows the quantification of the percentage of α-SMA positive cell areas (right; n = 3 per group). (b) qPCR analysis for the mRNA expression of SM α-actin and SM22αin abdominal aorta (n = 4 per group). (d) Western Blot analysis for the protein levels of myocardin in abdominal aorta (left). Bar graph shows the quantification relative to GAPDH level (right; n = 3 per group). Data expressed as mean ± S.E.M. *P < 0.05, **P < 0.01 vs saline. #P < 0.05 vs Ang II.

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