Table 1 Major variations of HPV-16 full length L1 sequence in cervical cancer.

From: Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico & in-vivo insight to vaccine development

S. No.

V1

V2

V3

V4

V5

V6

V7

V8

V9

V10

V11

V12

V13

V14

V15

V16

V16

Position

6163

6171

6240

6245

6314

6432

6557

6693

6719

6852

6863

6901

6590

6968

6992

7058

7058

Ref N

C

G

C

T

A

A

C

A

G

C

C

—

GAT

C

G

G

G

A

A

A

—

—

—

—

—

—

A

—

—

Ins ATC

DELETED

—

A

A

—

T

—

—

—

—

—

—

T

—

—

T

T

T

—

—

T

G

—

—

G

—

G

G

—

—

—

—

—

—

—

—

—

C

—

—

—

C

—

—

—

C

—

—

—

—

—

—

—

% of Sample

24.13

17.24

100

24.13

24.13

96.55

24.13

24.13

24.13

34.48

24.13

100

100

24.13

24.13

10.34

24.13

Ā 

202

205

228

—

—

292

—

379

—

—

435

448

465

—

—

—

500

Amino Acid

T—N

A—T

H—D

—

—

T-A

—

T-P

—

—

P-L

INS- S

DEL-D

—

—

—

L-F

Ā 

Polar-Polar

Non-Polar-Polar

Polar-Polar

Ā Ā 

Polar-Non-Polar

Ā 

Polar-Non Polar

Ā Ā 

Non Polar-Non Polar

Polar

Polar

Ā Ā Ā 

Non Polar-Non Polar

Hydrophobacity

Ā Ā 

Ā 

Ā Ā 

Ā Ā Ā Ā Ā