Table 2 Toxicity Screen for VEA constructs. Percent survival of chick embryos.

From: High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model

Reagent

n

24

48

72

Endotoxin

hours

hours

hours

(EU / mL)

PBS

40

100

100

87.5

0

LPS

5

0

0

0

1000

PVL 1

5

100

100

80

Lot 1: 3.14

PVL 1

5

100

100

100

Lot 2: 1.70

PVL 2

5

100

80

80

<0.5

PVL 5

5

100

80

80

4.54

PVL 6

5

100

100

80

Lot 1: 6.91; Lot 2: 1.40*

PVL 9

5

100

100

80

Lot 1: 7.86; Lot 2: 0.89*

PVL 10

5

100

100

100

6.58

  1. *Two lots of PVL6 and PVL9 were used for the vasopermeation studies, however, only the lot with the higher EU/mL (Lot 1 in each case) was used for the toxicity screen.
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