Table 2 Summary of stratified analyses by gender and subtypes of CHD for the variant rs3130933.

From: Evaluation of regulatory genetic variants in POU5F1 and risk of congenital heart disease in Han Chinese

Diagnostic groups

Genotype

Cases n (%)

Controls n (%)

MAFa

Crude OR (95%CI)

Adjusted ORb (95%CI)

Adjusted Pb

HeterogeneityPc

Cases

Controls

ASD

GG

726

3266

0.015

0.009

1.00

1.00

  
 

AG

21

59

  

1.60 (0.97–2.65)

1.51 (0.90–2.52)

1.19 × 10−1

 
 

AA

1

0

  

–

–

–

 
 

AG+AA

22

59

  

1.68 (1.02–2.76)

1.59 (0.96–2.64)

7.25 × 10−2

 
 

Additive

    

1.73 (1.07–2.80)

1.66 (1.01–2.71)

4.38 × 10 −2

 

VSD

GG

1458

3266

0.018

0.009

1.00

1.00

  
 

AG

63

59

  

2.39 (1.67–3.43)

2.32 (1.62–3.33)

5.21 × 10 −6

0.519

 

AA

1

0

  

–

–

–

 
 

AG+AA

64

59

  

2.43 (1.70–3.48)

2.36 (1.65–3.39)

3.03 × 10 −6

 
 

Additive

    

2.44 (1.71–3.48)

2.37 (1.66–3.39)

2.16 × 10 −6

 

ASD/VSD

GG

421

3266

0.021

0.009

1.00

1.00

  
 

AG

16

59

  

2.10 (1.20–3.69)

2.09 (1.19–3.68)

1.04 × 10 −2

 
 

AA

0

0

  

–

–

–

 
 

AG+AA

16

59

  

2.10 (1.20–3.69)

2.09 (1.19–3.68)

1.04 × 10 −2

 
 

Additive

    

2.10 (1.20–3.69)

2.09 (1.19–3.68)

1.04 × 10 −2

 
  1. aMinor allele frequency (MAF).
  2. bAdjusted for sex. Significant values (P < 0.05) are in bold.
  3. cP values for heterogeneity test between groups using ORs estimated in adjusted additive model.
Back to article page