Figure 5
Expected number of metastases generated from both type-1 and type-2 cells in different size categories.
The number of metastatic sites of the indicated sizes upon diagnosis on the x-axis by computational simulation (dots) and theoretical formulas (lines) when the primary tumor is diagnosed at (A) 1–3 cm and (B) 4–6 cm in diameter. Parameter values used are r = 0.11, d = 0.01r, a1 = 0.16, b1 = 0.01a1, a2 = 0.24, b2 = 0.01a2, a3 =0.58, b3 = 0.01a3, u1= u2 = 6.31×10−5 and q = q′ = 6.31×10−7, which are based on the estimation using time series clinical data in the pancreatic cancer autopsy program.
