Table 2 Association analysis between SNPs and Parkinson’s disease.
From: Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese
Gene | SNPa | allele A>Bb | case | control | MAF | P-value | OR (95% CI)e | |
|---|---|---|---|---|---|---|---|---|
AA/AB/BBb | AA/AB/BBb | Trendc (bonferronif) | LRd (bonferronif) | |||||
NPAS2 | rs930309 | T>A | 307/647/425 | 226/661/444 | 0.438 | 4.07 × 10−3 | 6.18 × 10−3 | 0.85 (0.77–0.95) |
NPAS2 | rs12479086 | G>A | 1031/315/37 | 1049/268/15 | 0.127 | 1.67 × 10−3 | 1.51 × 10−3 | 1.30 (1.11–1.53) |
CLOCK | rs3749474 | G>A | 195/663/535 | 165/603/569 | 0.364 | 2.56 × 10−2 | 2.88 × 10−2 | 0.88 (0.79–0.98) |
RORB | rs17611535 | G>A | 1140/237/14 | 1042/273/24 | 0.107 | 3.72 × 10−3 | 4.02 × 10−3 | 0.77 (0.65–0.92) |
ARNTL | rs900147 | G>A | 289/715/369 | 233/612/455 | 0.444 | 3.33 × 10−5 (4.23 × 10−3) | 5.13 × 10−5 (6.52 × 10−3) | 0.80 (0.71–0.89) |
ARNTL | rs7950226 | G>A | 447/704/238 | 493/639/198 | 0.407 | 8.84 × 10−3 | 6.84 × 10−3 | 0.86 (0.77–0.96) |
ARNTL | rs11605776 | C>A | 365/675/349 | 290/667/377 | 0.487 | 4.91 × 10−3 | 6.02 × 10−3 | 0.86 (0.77–0.95) |
ARNTL | rs10832022 | A>G | 405/683/299 | 435/666/232 | 0.443 | 4.77 × 10−3 | 7.16 × 10−3 | 1.17 (1.05–1.30) |
ARNTL | rs11022765 | C>A | 501/667/222 | 541/615/175 | 0.382 | 4.85 × 10−3 | 6.99 × 10−3 | 1.17 (1.05–1.31) |
ARNTL | rs1562437 | G>A | 39/421/926 | 52/463/809 | 0.197 | 1.33 × 10−3 | 1.36 × 10−3 | 0.81 (0.70–0.92) |
PER1 | rs2253820 | A>G | 630/632/121 | 711/501/88 | 0.289 | 5.30 × 10−6 (6.73 × 10−4) | 1.37 × 10−5 (1.74 × 10−3) | 1.31 (1.17–1.48) |
NR1D1 | rs3744805 | G>A | 231/610/512 | 245/646/409 | 0.416 | 2.94 × 10−3 | 2.43 × 10−3 | 1.18 (1.06–1.32) |
