Figure 3
From: Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery
ART sensitivity cluster.
(a) Annotations of genes affected by piggyBac insertions in each of the piggyBac mutants in the Kelch sensitivity cluster. (b) Initial chemogenomic profiling of 71 piggyBac mutants identified a cluster of 7 ART sensitive mutants, including the K13 Kelch mutant (piggyBac mutant 58). A. GO enrichment analysis of direct neighbors of K13 propeller from a gene-gene coexpression network identified pathways linked to K13 ascertain gene function. (c) Drugs and inhibitors showing a significant correlation with DHA. Metabolic pathways targeted by these compounds may reflect shared mechanisms of action with DHA and other artemisinin compounds.
