Figure 1

Intestinal tumor development is accompanied by infiltrating CD11b⁺ myeloid cells.

The number of CD11b⁺ myeloid cells increased in tumor tissues compared with the non-cancerous colonic tissues in CRC patients (a). The morphology of the colonic tissues was examined by H&E staining. The myeloid cell infiltration was detected by IF in the tumor tissues of CRC patients. CD11b⁺ myeloid cells were increased in tumor tissues compared with the normal small intestine tissues of Apc^Min/+ mice (b). The morphology of the colonic tissues was examined by H&E staining. The myeloid cell infiltration was detected by IF in the tumor tissues of Apc^Min/+ mice. The numbers of CD11b⁺ myeloid cells in the bone marrow (c), spleen (d) and peripheral blood (e) were analyzed by FACS gated on CD45⁺ leukocytes. The results of H&E and IF staining are representative of 11 independent CRC patients or Apc^Min/+ mice (all mice were 16-weeks-old). The statistical data are expressed as the means ± S.D. **P <0.01 and ns: P > 0.05. Scale bars: 50 μm.