Figure 3
From: H2S, a novel gasotransmitter, involves in gastric accommodation
Effect of H2S signal pathway on IGP in vivo.
Representative recordings of the effects of L-Cys on IGP (a).The rate of IGP decrease was significantly larger upon pretreatment with the L-Cys (1 mM) than that of control group, which was reduced by AOAA, an inhibitor for CBS (b). Plateau IGPs were not affected by pretreatment with either L-Cys or AOAA (c). Notably, either exogenous H2S donor NaHS or CSE inhibitor PAG had no effect on IGP. Furthermore, the descent rate of IGP was lower in CBS+/− mice than that of littermate wild-type mice (d,e). Rate of IGP descent: the rate of pressure decrease within 20 s. Plate of IGP: difference between plateau pressure and basal pressure. n = 4–6; *P < 0.05; **P < 0.01.
