Figure 3

Apelin-treatment protects from mitochondrial damage, H2O2 production and lipid peroxidation in obese heart.
(A) Typical electron micrographs from sham (S), apelin-treated (A) or animals subjected to I/R are shown at original magnifications x1500 and x10000. (B) Quantitative analysis of mitochondrial density in heart tissues. (C) qRT-PCR analysis of mtDNA content. (D,E), Plasmatic LPO (D) and H2O2 levels in cardiac tissues (E) from obese mice treated as indicated. *p < 0.05; ***p < 0.001 vs S; #p < 0.05 vs I/R.