Table 2 Characteristics of the patients with HF.

From: Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity

 

All HF

non-obese HF

obese HF

 

(N = 40)

(N = 27)

(N = 13)

P

Age, y

64 ± 9

63 ± 10

66 ± 7

0.305

Sex, Female, % (F/M)

12 (5/35)

15 (4/23)

8 (1/12)

0.653

BMI

27.6 ± 5.1

24.8 ± 2.6

33.2 ± 4.6.

<0.001

Cardiovascular risk factors

 Hypertensive, % (n)

40 (16)

41 (11)

39 (5)

1.000

 T2-Diabetes, % (n)

35 (14)

22 (6)

61 (8)

0.031

 Dyslipedemia, % (n)

45 (18)

37 (10)

61 (8)

0.185

 Smoking, % (n)

10 (4)

11 (3)

8 (1)

1.000

 Heart failure etiology

 Ischemic CM, % (n)

60 (24)

56 (15)

69 (9)

0.503

 Valvular CM, % (n)

5 (2)

7 (2)

0 (0)

0.550

 Dilated CM, % (n)

35 (14)

37 (10)

31(4)

0.740

Medication

 ACEIs, % (n)

72 (29)

74 (20)

69 (9)

1.000

 ARBs, % (n)

15 (6)

11 (3)

23 (3)

0.370

 Beta-blockers, % (n)

90 (36)

92 (25)

85 (11)

0.583

 Diuretics, % (n)

67 (27)

74 (20)

53 (7)

0.100

 Vitamin K antagonists, % (n)

45 (18)

52 (14)

31 (4)

0.312

 Antiplatelet agents, % (n)

67 (27)

63 (17)

77 (10)

0.484

 Statines, % (n)

65 (26)

59 (16)

77 (10)

0.316

Admission labs

 BNP, pmol/ml

450 [245–957]

614 [326–1487]

214 [127–774]

0.073

 Creatinine, μmol/l

101 [96–124]

103 [93–134]

100 [82–143]

0.817

 C reactive protein, mg/l

7.8 [3.5–11.6]

8.1 [2.7–13.6]

7.8 [3.3–14.7]

0.858

 Na+ mM

138 ± 3

138 ± 3

138 ± 3

0.523

 ALT, U/ml

29 [25–36]

26 [19–38]

32 [26–48]

0.311

Admission vitals

 Mean Blood Pressure, mmHg

86 ± 12

83 ± 11

91 ± 12

0.035

 Heart rate, Bpm

73 ± 16

75 ± 16

70 ± 17

0.449

Echocardiography

 LVEF, %

31 ± 13

27 ± 10

39 ± 13

0.003

 LVEF  <  30%, % (n)

42 (17)

52 (14)

23 (3)

0.103

NYHA class

 II, % (n)

60 (24)

55 (15)

69 (9)

0.503

 III, % (n)

35 (14)

37 (10)

31(4)

0.740

 IV, % (n)

5 (2)

4 (1)

8 (1)

1.000

  1. CHF, cardiac heart failure; BMI, body mass index; CM, cardiomyopathy; ACEIs, angiotensin-converting enzyme inhibitors; ARBs, angiotensin II receptor blockers; BNP, B-type natriuretic peptide concentration; ALT, alanine aminotransferase; LVEF, left ventricular ejection fraction; NYHA class, New York Heart Association functional classification.