Table 2 Association of germline mutations and clinical-pathological characteristics.

From: Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer

 

Mutation +

Mutation −

p-value

N

35

26

 

Female: Male

28:7

20:6

0.77

Age

43.26 ± 9.66

47.19 ± 13.02

0.18

Tumor size

1.05 ± 0.50

1.01 ± 0.47

0.73

Multifocality

16(45.7%)

10(42.3%)

0.79

Bilaterality

12(34.3%)

8(34.6%)

0.98

Total thyroidectomy

15(42.9%)

12(46.2%)

0.80

Central compartment neck dessection

34(97.1%)

25(96.2%)

0.83

Extrathyroidal extension

16(45.7%)

14(53.9%)

0.53

Central lymph node involvement

24(68.6%)

8(30.8%)

0.003

Lateral lymph node involvement

7(20.0%)

6(23.1%)

0. 77

  1. Proportions were compared using Fisher’s exact test or Chi-square test and continuous variables were compared using Student’s t-test or Mann Whitney U-test, as appropriate. A p-value < 0.05 was considered statistically significant.
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