Figure 3
From: A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase
Modeling of compound 1 (carbon atoms in yellow) in Btk’s active site (PDB code 3PJ3).
The light blue dots indicate potential hydrogen bonds between compound 1 and Btk. Cys481 is at the C-terminus of the hinge region.
