Figure 1 | Scientific Reports

Figure 1

From: Ventral tegmental area dopamine and GABA neurons: Physiological properties and expression of mRNA for endocannabinoid biosynthetic elements

Figure 1

Electrophysiological properties of rat and mouse DA and GABA cells.

(A) Selected examples of electrophysiological profiles of VTA dopaminergic and GABAergic neurons. Scale bars represent 35 mV and 500 msec for all traces. Positive current injection was either 100 or 150 pA in each and hyperpolarizing current injected was −200 pA. DA neurons were identified by expression of TH or DAT and GABA neurons were identified by expression of GAD65 or GAD67. (B) Sag potential amplitude increases in a linear manner with increasing negative current injection and while overlapping in some cases, differs significantly (p < 0.003, ANCOVA) between rat DA (black) and GABA (gray) neurons. (C) Sag potential amplitude increases in a linear manner with increasing negative current injection in mouse GABA neurons, which were also not significantly different from rat GABA cells (p = 0.85, ANCOVA), but were significantly different from rat DA neurons (p < 0.01, ANCOVA).

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