Table 10 Stratification analysis: association between factors [residual tumor ratio, second surgery (yes vs. no), pre-operative testosterone level] and risk of long-tern testosterone therapy, by multivariate logistic regression stratified by pre-operative tumor volume.

From: Prediction of Long-term Post-operative Testosterone Replacement Requirement Based on the Pre-operative Tumor Volume and Testosterone Level in Pituitary Macroadenoma

Stratification: pre-operative tumor volume

N

Area under curve

Residual tumor ratio, per 0.1 increase

Second surgery, yes vs. no

Pre-operative testosterone level, per 0.5 increase

P value

Adjusted OR(95% CI)

P value

Adjusted OR(95% CI)

P value

Adjusted OR(95% CI)

<7 cm3

23

0.855

0.2723

0.356 (0.056–2.251)

0.1923

37.097 (0.162–999.999)

0.1301

0.453 (0.163–1.263)

≥7 cm3

29

0.917

0.0367

4.713 (1.100–20.189)

0.9797

999.999 (0.001–999.999)

0.0255

0.248 (0.073–0.843)

<8 cm3

23

0.855

0.2723

0.356 (0.056–2.251)

0.1923

37.097 (0.162–999.999)

0.1301

0.453 (0.163–1.263)

≥8 cm3

29

0.917

0.0367

4.713 (1.100–20.189)

0.9797

999.999 (0.001–999.999)

0.0255

0.248 (0.073–0.843)

<9 cm3

26

0.854

0.3267

1.446 (0.692–3.019)

0.2245

20.260 (0.158–999.999)

0.0971

0.439 (0.166–1.161)

≥9 cm3

26

0.909

0.0429

4.336 (1.048–17.940)

0.9801

999.999 (0.001–999.999)

0.0236

0.237 (0.068–0.824)

<10 cm3

30

0.888

0.3335

1.436 (0.690–2.987)

0.1166

32.151 (0.421–999.999)

0.0438

0.401 (0.165–0.975)

≥10 cm3

22

0.862

0.0608

4.066 (0.983–17.620)

0.9980

3.387 (0.001–999.999)

0.0396

0.253 (0.068–0.937)

<11 cm3

36

0.914

0.3617

1.379 (0.691–2.751)

0.0850

75.607 (0.550–999.999)

0.0270

0.326 (0.121–0.880)

≥11 cm3

16

0.744

0.1855

3.104 (0.580–16.601)

N/A

N/A

0.1392

0.310 (0.066–1.464)

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